Why You're Not Losing Weight on Ozempic, Wegovy, or Mounjaro — It Might Not Be Your Dose

If you’ve hit a weight loss plateau on Ozempic or Wegovy, PCOS or thyroid issues might be the reason. Learn what labs to order and how to fix it.

Published on:
March 30, 2025

Why You're Not Losing Weight on GLP-1s — Could PCOS or Thyroid Be the Culprit?

You started a GLP-1 medication like Ozempic, Wegovy, or Mounjaro (semaglutide or tirzepatide) to lose weight — and at first, it worked. But now you’re stuck. The scale isn’t moving, and you're wondering why.

Here’s the truth: it’s probably not your dose.
Hidden hormone issues like PCOS or thyroid imbalances could be getting in the way.

  • Up to 1 in 10 women have PCOS — and it’s up to 70% more common in overweight women.
  • Thyroid conditions like hypothyroidism or Hashimoto’s are also common and frequently go undiagnosed.

Both can disrupt your metabolism, hormones, and energy levels — making fat loss more difficult even with powerful medications like GLP-1s.

Stay ahead in your GLP-1 journey—get expert insights, tracking tips, and exclusive updates